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丝裂霉素C,Mitomycin C From Sigma-M4287

 

产品编号 M4287 | CAS号 50-07-7 | SIGMA
丝裂霉素 C 来源于头状链霉菌

Mitomycin C from Streptomyces caespitosus
powder, BioReagent, suitable for cell culture
安全技术说明书
经验分子式(希尔表示法) C15H18N4O5  分子量 334.33   Beilstein Registry Number 7231816  MDL number MFCD00078109   PubChem Substance ID 24896917
POPULAR DOCUMENTS:  PRODUCT INFORMATION SHEET (PDF)  |  SPECIFICATION SHEET (PDF)
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
Mitomycin C is produced by a strain of actinomyces, Streptomyces caespitosus. It contains three anticancer moieties, quinine, urethane, and aziridine groups. It is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems.
Biochem/physiol Actions
DNA 合成、细胞核分裂和癌细胞的抑制剂。对革兰氏阳性菌、革兰氏阴性菌、抗酸杆菌有抗菌性。
Caution
This vial contains 2 mg Mitomycin C and 48 mg NaCl. Stock solutions should be filter sterilized and stored at 2-8°C in the dark. Solutions at pH 6-9 can be stored at 0-5°C for up to a week, but if a precipitate forms, a fresh solution should be prepared - the precipitated solution has been proven toxic to cells.
Preparation Note
Mitomycin C is soluble in water at .5 mg/mL, with a pH of 6.0-7.5. It undergoes rapid degradation in acidic solutions with pH<6, and is mostly likely to retain activity in solutions with a pH between 6-9.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information
Related Categories Antibiotic powders, Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application,
更多...
product line   BioReagent
form   powder
solubility   H2O: soluble4 mL/vial, clear to slightly hazy, blue to purple (Stock solutions should be filter sterilized and stored at 2-8 °C in the dark.)
suitability   suitable for cell culture
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

 
 
 
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